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Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus 认领 引用
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作者 Jiawei Xiao Donghua Guo +17 位作者 Xiaoxu Xing Limin Jiang Shanshan Qi Jun Wang Wenfei Bai Shiping Yu Fanbo Shen Xingyang Guo Xinglin Wang Wei Zhou Hansong Li Feiyu Zhao Li Feng Jialin Zhang Yaru Xu Dan Yang Haixin Liu Dongbo Sun 《Virologica Sinica》 SCIE CAS CSCD 2026年第1期208-226,共19页
Swine enteric coronaviruses(SECoVs)cause severe watery diarrhea and high mortality in piglets,resulting in significant economic losses to the global pig industry.However,frequent mutations in SECoVs significantly comp... Swine enteric coronaviruses(SECoVs)cause severe watery diarrhea and high mortality in piglets,resulting in significant economic losses to the global pig industry.However,frequent mutations in SECoVs significantly compromise vaccine-induced immunity and limit cross-protection against emerging variants.Therefore,there is an urgent need to develop new broad-spectrum antiviral drugs to be the last line of defense to supplement vaccine immunity.In this study,we utilized molecular docking and molecular dynamics simulations to identify phloretin as a broad-spectrum SECoV inhibitor.Phloretin has demonstrated prophylactic and therapeutic efficacy in vitro and in vivo,improving the survival of SECoV-infected piglets.It was further found that phloretin exerts a broad-spectrum antiviral effect by acting on the conserved 3CLpro Cys144 site of three SECoVs.It is worth noting that derivative A12,designed on the basis of the structure-activity relationship(SAR)between phloretin and 3CLpro,showed a 15.7,2.6,and 8.4-fold increase in antiviral effect against porcine epidemic diarrhea virus(PEDV),transmissible gastroenteritis virus(TGEV),and porcine delta coronavirus(PDCoV),respectively.This study reveals a 3CLpro Cys144 targeting broad-spectrum strategy for use against SECoVs,providing a candidate drug to bridge the vaccine immunity gap. 展开更多
关键词 Phloretin Swine enteric coronaviruses 3C-like protease Broad-spectrum antiviral Structural modification
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A comprehensive multi-organ proteomic atlas of human aging across 50 years 认领 引用
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作者 Wenjing Dong Payton Klosa +3 位作者 Andreas Beyer Xueqiu Lin Chun Liu 无 《Protein & Cell》 SCIE CAS CSCD 2026年第4期275-278,共4页
Multi-organ map of aging by proteomics Aging leads to a progressive decline in tissue function and structure across all organ systems,underlying the risk of various chronic diseases(Guo et al.,2022).Although studies i... Multi-organ map of aging by proteomics Aging leads to a progressive decline in tissue function and structure across all organ systems,underlying the risk of various chronic diseases(Guo et al.,2022).Although studies in animals have shown that different organs have distinct aging rates,the molecular trajectories of aging across different human organs remain largely unexplored(Oh et al.,2023). 展开更多
关键词 proteomics aging multi organ map proteomic atlas molecular trajectories tissue function structure chronic diseases guo human organs human aging
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