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A Spectrum Allocation and Security-Sensitive Task Offloading Algorithm in MEC Using DVS 认领 引用
1
作者 Xianwei Li Bo Wei +3 位作者 Xiaoying Yang Amr Tolba Zijian Zeng Osama Alfarraj 《Computers, Materials & Continua》 SCIE EI 2025年第11期3437-3455,共19页
With the advancements of the next-generation communication networking and Internet ofThings(IoT)technologies,a variety of computation-intensive applications(e.g.,autonomous driving and face recognition)have emerged.Th... With the advancements of the next-generation communication networking and Internet ofThings(IoT)technologies,a variety of computation-intensive applications(e.g.,autonomous driving and face recognition)have emerged.The execution of these IoT applications demands a lot of computing resources.Nevertheless,terminal devices(TDs)usually do not have sufficient computing resources to process these applications.Offloading IoT applications to be processed by mobile edge computing(MEC)servers with more computing resources provides a promising way to address this issue.While a significant number of works have studied task offloading,only a few of them have considered the security issue.This study investigates the problem of spectrum allocation and security-sensitive task offloading in an MEC system.Dynamic voltage scaling(DVS)technology is applied by TDs to reduce energy consumption and computing time.To guarantee data security during task offloading,we use AES cryptographic technique.The studied problem is formulated as an optimization problem and solved by our proposed efficient offloading scheme.The simulation results show that the proposed scheme can reduce system cost while guaranteeing data security. 展开更多
关键词 IoT DVS MEC AES
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New energy policy and low-carbon society in Japan after the Great East Japan Earthquake 认领 引用
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作者 Ryuji Matsuhashi Kae Takase +1 位作者 Koichi Yamada Hiroshi Komiyama 《Chinese Journal of Population,Resources and Environment》 2013年第1期62-68,共7页
The Great East Japan Earthquake in March 2011 devastated the eastern region of Japan.Due to the resulting nuclear accident,Japanese Cabinet decided to revise its energy policies.The Energy and Environment Council in N... The Great East Japan Earthquake in March 2011 devastated the eastern region of Japan.Due to the resulting nuclear accident,Japanese Cabinet decided to revise its energy policies.The Energy and Environment Council in National Policy Unit published options on the nation's scenarios for energy and economy in 2030.We estimated the economic impacts of the options to national economy and households in 2030.Finally,we clarified significant factors to establish a secure,affluent and low-carbon society based on the energy scenarios. 展开更多
关键词 Great East Japan Earthquake energy scenarios the Energy and Environment Council Affluent Low-carbon Society CO_2 emissions
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Analysis on Composition and Antioxidative Properties of Phlorotannins Isolated from Japanese Eisenia and Ecklonia Species 认领 引用
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作者 Toshiyuki Shibata Kohki Nagayama +3 位作者 Shingo Sugiura Saki Makino Mitsuyoshi Ueda Yutaka Tamaru 《American Journal of Plant Sciences》 CAS 2015年第15期2510-2521,共12页
The composition and antioxidative properties of crude phlorotannins isolated from Japanese Eisenia and Ecklonia species including cultured E. kurome were analyzed. As a result of liquid chromatography mass spectrometr... The composition and antioxidative properties of crude phlorotannins isolated from Japanese Eisenia and Ecklonia species including cultured E. kurome were analyzed. As a result of liquid chromatography mass spectrometry analysis, it was suggested that the phlorotannins were composed of compounds containing 3 - 7 phloroglucinol units for Eisenia species and 3 - 8 phloroglucinol units for Ecklonia species. The antioxidant properties of phlorotannins were evaluated using the hydrophilic oxygen radical absorbance capacity (H-ORAC) assay, the measurements of superoxide anion radical scavenging activity (SOSA) with electron spin resonance method, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay. It was clarified that the phlorotannins contained H-ORAC values of 8.9 × 103 - 1.0 × 104 μmol-Trolox equivalents (TE)/g, SOSA of 1.5 × 104 - 2.9 × 104 superoxide dismutase units/g, DPPH radical scavenging activity of 4.7 × 103 - 5.5 × 103 μmol-TE/g, and reducing power of 6.5 × 102 - 7.0 × 102 mg-ascorbic acid equivalents/g, and had excellent antioxidative properties. 展开更多
关键词 Eisenia Species Ecklonia Species Cultured E. kurome H-ORAC Phlorotannins Radical Scavenging Activities
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Mathisson-Papapetrou force on wedge disclinations 认领 引用
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作者 Cheng Yuan Xiao-Wen Lei +1 位作者 Toshiyuki Fujii Kazuyuki Shizawa 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第4期383-395,共13页
In this study,we derive a more generalized form of the Mathisson-Papapetrou force equation and perform an indepth analysis of the variation in the Mathisson-Papapetrou force between two wedge disclinations across diff... In this study,we derive a more generalized form of the Mathisson-Papapetrou force equation and perform an indepth analysis of the variation in the Mathisson-Papapetrou force between two wedge disclinations across different calculation models in a two-dimensional plane.The results demonstrate that the stress field magnitude along the x1 and x2 axes consistently remains zero,facilitating the wedge disclination dipole in achieving equilibrium state along these two directions within the plane.Furthermore,the stress field enables the Mathisson-Papapetrou force acting on one wedge disclination in semicircular motion to be approximated by the force in linear motion within the same two-dimensional plane.This study contributes a more comprehensive understanding of wedge disclination by deriving a generalized Mathisson-Papapetrou force equation applicable to disclinations. 展开更多
关键词 Wedge disclination Mathisson-Papapetrou force Equilibrium state Stress field
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NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis 认领 引用 被引量：22
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作者 Norihide Higuchi Naoko Tahara +14 位作者 Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto 《World Journal of Gastroenterology》 SCIE CAS 2007年第45期6003-6008,共6页
AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treat... AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. 展开更多
关键词 Tuberculosis Anti-tuberculosis drugs Drug-induced hepatotoxicity NAT2-haplotype DNA-baseddiagnosis
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DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus 认领 引用 被引量：15
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作者 Keisuke Matsusaka Sayaka Funata +1 位作者 Masashi Fukayama Atsushi Kaneda 《World Journal of Gastroenterology》 SCIE CAS 2014年第14期3916-3926,共11页
Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric cancer.In particular,the development of genome-wide analysis tools has enabled... Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric cancer.In particular,the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer;for example,aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric carcinogenesis.The etiological viewpoint is also essential for the study of gastric cancers,and two distinct pathogens,Helicobacter pylori(H.pylori)and Epstein-Barr virus(EBV),are known to participate in gastric carcinogenesis.Chronic inflammation of the gastric epithelium due to H.pylori infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric cancer.In addition,EBV infection is known to cause extensive methylation,and EBV-positive gastric cancers display a high methylation epigenotype,in which aberrant methylation extends to not only Polycomb repressive complex(PRC)-target genes in embryonic stem cells but also non-PRC-target genes.Here,we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with H.pylori and EBV. 展开更多
关键词 Gastric cancer Epigenetics DNA methylation Epstein-Barr virus Helicobacter pylori
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Synthesis of anatase TiO2 with exposed {001} and {101} facets and photocatalytic activity 认领 引用 被引量：10
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作者 Jia Sun Ming Zhang +4 位作者 Zhi-Feng Wang Hai-Yan Chen Ye Chen Naoya Murakami Teruhisa Ohno 《Rare Metals》 SCIE EI CAS CSCD 2019年第4期287-291,共5页
Anatase titanium(IV)oxide(TiO2)particles with exposed{001}and{101}facets were prepared by hydrothermal treatment of amorphous TiO2 with H2O2-NH3 solution.Crystal phase,shape,and size of TiO2 particle... Anatase titanium(IV)oxide(TiO2)particles with exposed{001}and{101}facets were prepared by hydrothermal treatment of amorphous TiO2 with H2O2-NH3 solution.Crystal phase,shape,and size of TiO2 particles are found to be greatly dependent on the ratio of H2O2-NH3 solution.The prepared TiO2 particles with specific exposed crystal faces show higher photocatalytic activity for acetaldehyde decomposition than commercial spherical TiO2 particles.This result implies that recombination is prevented by spatial separation of redox sites in the particles because of selective migration of electrons and positive holes to specific exposed crystal faces and/or different reactivity of electrons and positive holes on the specific exposed crystal face. 展开更多
关键词 Anatase {001} and {101} facets H2O2-NH3
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A Novel Hollow-Core Holey Fibre with Random Hole Distributions in the Cladding 认领 引用 被引量：2
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作者 杨旅云 陈丹平 +4 位作者 达宁 周秦岭 姜雄伟 朱从善 邱建荣 《Chinese Physics Letters》 SCIE EI CAS 2005年第10期2592-2594,共3页
We provide a novel hollow-core holey fibre that owns a random distribution of air holes in the cladding. Our experiments demonstrate that many of the features previously attributed to photonic crystal fibres with perf... We provide a novel hollow-core holey fibre that owns a random distribution of air holes in the cladding. Our experiments demonstrate that many of the features previously attributed to photonic crystal fibres with perfect arrangement of air holes, in particular, photonic bandgap guidance, can also be obtained in the fibre. Additionally, this fibre exhibits a second guided mode with both the two-lobe patterns, and each pattern is in different colour. 展开更多
关键词 PHOTONIC CRYSTAL FIBER GUIDANCE AIR
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Nanofluidic Manipulation of Single Nanometric Objects:Current Progress,Challenges,and Future Opportunities 认领 引用 被引量：1
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作者 Nattapong Chantipmanee Yan Xu 《Engineering》 SCIE EI CAS CSCD 2024年第12期54-71,共18页
The manipulation of nanometric objects,encompassing both non-biological and biological objects,offers a transformative avenue for breakthroughs in diverse fields,such as chemistry,biology,chemical and biomedical engin... The manipulation of nanometric objects,encompassing both non-biological and biological objects,offers a transformative avenue for breakthroughs in diverse fields,such as chemistry,biology,chemical and biomedical engineering,materials and mechanical engineering,and various industrial applications.However,achieving accuracy,precision,and high throughput in the manipulation of nanometric objects,whether on the scale of a single nanometric entity or molecule,is a formidable challenge because of the extremely small dimensions involved.Nanofluidics has already demonstrated unique capabilities for transporting the mass of ions and small molecules at the nanoscale.We posit that chip-based nanofluidic devices provide potent strategies for the precise,accurate,and high-throughput manipulation of single nanometric entities and molecules,benefiting from their dimensions,which are comparable to those of nanometric objects.This article offers an overview of the current progress in nanofluidic manipulation of single nanometric objects.It also discusses the challenges in the development of nanofluidic manipulation technologies.Furthermore,the article explores future opportunities in the field,highlighting possible solutions to the challenges,and aims to contribute to the ongoing discourse on nanofluidic manipulation,thus propelling the field to overcome its current limitations. 展开更多
关键词 Nanochannels Microfluidics Single entities Nanoparticles DNA Proteins Vesicles Viruses
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The roles of tubulin-folding cofactors in neuronal morphogenesis and disease 认领 引用
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作者 Misako Okumura Masayuki Miura Takahiro Chihara 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第9期1388-1389,共2页
Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep ... Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep process assisted by at least five tubulin-fold- ing cofactors （TBCA-E） （Lopez-Fanarraga et al., 2001）. Newly syn- thesized α- and β-tubulins associate with the cytosolic chaperonin complex （CCT）, and then the quasi-native tubulins interact with five tubulin-folding cofactors. The α- and β-tubulins first interact with TBCB and TBCA, which are further transferred to TBCE and TBCD, respectively. The α- and β-tubulins, TBCC, TBCD, and TBCE form a supercomplex, and guanosine triphosphate （GTP） hydrolysis occurs within the supercomplex, releasing a tubulin heterodimer. In addition to their functions in tubulin folding and tubulin heterodimer formation, excess amounts of TBCD or TBCE may interact with tubulin heterodimers, leading to their degrada- tion. Thus, tubulin-folding cofactors may play a role in both the synthesis and degradation of tubulin heterodimers. 展开更多
关键词 The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure
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Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma 认领 引用 被引量：10
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作者 Chikako Shibata Motoyuki Otsuka +4 位作者 Takahiro Kishikawa Motoko Ohno Takeshi Yoshikawa Akemi Takata Kazuhiko Koike 《World Journal of Hepatology》 2015年第1期1-6,共6页
Micro RNAs(mi RNAs) are small,noncoding RNA molecules that regulate gene expression posttranscriptionally,targeting thousands of messenger RNAs. Long noncoding RNAs(lnc RNAs),another class of noncoding RNAs,have been ... Micro RNAs(mi RNAs) are small,noncoding RNA molecules that regulate gene expression posttranscriptionally,targeting thousands of messenger RNAs. Long noncoding RNAs(lnc RNAs),another class of noncoding RNAs,have been determined to be also involved in transcription regulation and translation of target genes. Since deregulated expression levels or functions of miR NAs and lncR NAs in hepatocellular carcinoma(HCC) are frequently observed,clinical use of noncoding RNAs for novel diagnostic and therapeutic applications in the management of HCCs is highly and emergently e xpe c t e d. H e r e,we s ummar iz e r e c e nt f indings regarding deregulated mi RNAs and lnc RNAs for their potential clinical use as diagnostic and prognostic biomarkers of HCC. Specifically,we emphasize the deregulated expression levels of such noncoding RNAs in patients' sera as noninvasive biomarkers,a field that requires urgent improvement in the clinical surveillance of HCC. Since nucleotide-based strategies are being applied to clinical therapeutics,we further summarize clinical and preclinical trials using oligonucleotides involving the use of miR NAs and small interfering RNAs against HCC as novel therapeutics. Finally,we discuss current open questions,which must be clarified in the near future for realistic clinical applications of these new strategies. 展开更多
关键词 MicroRNA Long noncoding RNA Hepatocellularcarcinoma Clinical trials Biomarker
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Nanofluidics for sub-single cellular studies:Nascent progress,critical technologies,and future perspectives 认领 引用 被引量：1
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作者 Jinbin Yang Yan Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第6期2799-2806,共8页
In the field of cell studies,there is a burgeoning trend to further downscale the investigation from a single-cell level to a sub-single-cell level.Subcellular matter is the basic content in cells and correlates with ... In the field of cell studies,there is a burgeoning trend to further downscale the investigation from a single-cell level to a sub-single-cell level.Subcellular matter is the basic content in cells and correlates with cell heterogeneity.Sub-single cellular studies focus on the subcellular matter in single cells and aim to understand the details and heterogeneity of individual cells in terms of the subcellular matter or even at the single component/vesicle/molecule level.Hence,sub-single cellular studies can provide deeper insights into fundamental cell biology and the development of new diagnostic and therapeutic technologies and applications.Nonetheless,the contents of a single cell are not only ultra-small in volume but also extremely complex in composition,far exceeding the capabilities of most tools used in current cell studies.We believe that nanofluidics holds great potential in providing ideal tools for sub-single cellular studies,not only because of their capability to handle femtoliter/attoliter-scale samples,but also because of their possibility to manipulate and analyze subcellular matters at the single component/vesicle/molecule level in a high-throughput manner.In this review,we summarize the efforts in the field of nanofluidics for sub-single cellular studies,focusing on nascent progress and critical technologies that have the potential to overcome the technical bottlenecks.Some challenges and future opportunities to integrate with information sciences are also discussed. 展开更多
关键词 Sub-single cellular matter Single cell Single molecule Extracellular vesicles Nanochannel Femtoliter Attoliter Digital Information sciences
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Luminescent Cu(Ⅰ) and Ag(Ⅰ) coordination polymers:Fast phosphorescence or thermally activated delayed fluorescence 认领 引用
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作者 Gangyuan Li Hao Ye +5 位作者 Fucheng Zhu Yan Geng Jianzhong Fan Jianping Ma Chihaya Adachi Yu-Bin Dong 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第11期1931-1934,共4页
By applying two donor-acceptor motif molecules,5,10-di(pyridin-4-yl)-5,10-dihydrophenazine(L1)and 10,10'-di(pyridin-3-yl)-10H,10'H-9,9'-spiroacridine(L2),as ligands and CuI/AgCF3CO2 as metal salt,we synthe... By applying two donor-acceptor motif molecules,5,10-di(pyridin-4-yl)-5,10-dihydrophenazine(L1)and 10,10'-di(pyridin-3-yl)-10H,10'H-9,9'-spiroacridine(L2),as ligands and CuI/AgCF3CO2 as metal salt,we synthesized three coordination polymers,namely,{Cu4(L1)2I4}(CP1),{Cu(L2)I·CHCl3}(CP2)and{Ag(L2)CO2CF3·CHCl3}(CP3).X-ray crystallographic analysis revealed that three coordination polymers all feature one-dimensional(1D)linear chains which are consisting of molecular boxlike units.In comparison with low photoluminescence quantum yield(PLQY)of two ligands,three coordination polymers,CP1,CP2 and CP3,present more intense photoluminescence with PLQY of 15%,46%and 34%at room temperature respectively.The PL emission of CP1 and CP2 at room temperature could be attributed to the fast phosphorescence with lifetime both around 5 ms due to effective intersystem crossing(ISC).Whilst,it is worth noting that CP3 exhibit thermally activated delayed fluorescence(TADF)emission at room temperature. 展开更多
关键词 Coordination polymers Phosphorescence Thermally activated delayed fluorescence Photoluminescence quantum yield Intersystem crossing
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Spin Interference in Rectangle Loop Based on Rashba and Dresselhaus Spin-Orbit Interactions 认领 引用
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作者 倪佳婷 梁小婉 +1 位作者 陈斌 T.Koga 《Chinese Physics Letters》 SCIE EI CAS 2009年第12期210-212,共3页
We demonstrate the amplitude and spin polarization of AAS oscillation changing with Rashba spin-orbit interaction （SOI） and Dresselhaus SOI. The amplitude and spin polarization of AB oscillation changing with Rashba... We demonstrate the amplitude and spin polarization of AAS oscillation changing with Rashba spin-orbit interaction （SOI） and Dresselhaus SOI. The amplitude and spin polarization of AB oscillation changing with Rashba SOI and Dresselhaus SOI are demonstrated as well. The ideal quasi-one-dimensional square loop does not exist in reality, therefore to match the experiment better we should consider the shape of the rectangle loop in theory. 展开更多
关键词 Chinese climate network complex systems small world community
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Photovoltaics and Photoexcited Carrier Dynamics of Double-Layered CdS/CdSe Quantum Dot-Sensitized Solar Cells 认领 引用 被引量：1
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作者 Taro Toyoda Yohei Onishi +3 位作者 Kenji Katayama Tsuguo Sawada Shuzi Hayase Qing Shen 《材料科学与工程（中英文A版）》 2013年第9期601-608,共8页
The photovoltaics of double-layered CdS/CdSe quantum dot （QD）-sensitized solar cells （QDSCs） were investigated. The CdS/CdSe quantum dot was adsorbed on inverse opal （IO）-TiO2. IO-TiO2 electrode has a honeycomb ... The photovoltaics of double-layered CdS/CdSe quantum dot （QD）-sensitized solar cells （QDSCs） were investigated. The CdS/CdSe quantum dot was adsorbed on inverse opal （IO）-TiO2. IO-TiO2 electrode has a honeycomb structure with large inter connected pores that lead to better infiltration despite the smaller surface area than nanoparticulate electrode. Animprovement in the photovoltaic conversion efficiency （- 3.8%） was achieved compared with single-layered CdSe-QDSCs （- 2.9%）. The ultrafast photoexcited carrier dynamics （the electron and hole relaxation processes） of CdS/CdSe-QDSCs were investigated by improved-transient grating （TG） technique.TG technique basically depends on the refractive index changes due to photoexcited carriers. The ultrafast carrier dynamics of CdS/CdSe- and CdSe-QDSCs show fast （hole） and slow （electron） relaxation processes with decay times of a few picoseconds and a few tens of picoseconds, respectively. Theelectron relaxation time was shorter in the CdS/CdSe-QDSCs than in the CdSe-QDSCs, indicating a reduction in the numbers of recombination centers due to the pre-adsorbed CdS QDs layer. 展开更多
关键词 CdSe量子点 太阳能电池 子动力学 载流子 光伏 敏化 光生 TiO2电极
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Deciphering tumor-suppressor signaling in flies:Genetic link between Scribble/Dlg/Lgl and the Hippo pathways 认领 引用
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作者 Masato Enomoto Tatsushi Igaki 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2011年第10期461-470,共10页
Loss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression, scribbleldiscs largellethal giant larvae （scrib/dlg/lgl）, a group of apico-basal polarity genes, were initially id... Loss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression, scribbleldiscs largellethal giant larvae （scrib/dlg/lgl）, a group of apico-basal polarity genes, were initially identified as members of ＂neoplastic＂ tumor-suppressors in flies. The components of the Hippo signaling pathway, which is crucial for organ size control and cancer development, were also identified through Drosophila genetic screens as members of ＂hyperplastic＂ tumor-suppressors. Accumulating evidence in recent studies implies that these two tumor-suppressor signaling pathways are not mutually exclusive but rather cooperatively act to give rise to highly malignant tumors. The interaction of these tumor-suppressor pathways could include deregulations of actin cytoskeleton, cell-cell contact, and apical-domain size of 展开更多
关键词 Cell polarity Hippo pathway Drosophila scribble dlg lgl Tumor-suppressor Tumor progression
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New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brainrelated diseases 认领 引用 被引量：33
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作者 Naoki Adachi Tadahiro Numakawa +2 位作者 Misty Richards Shingo Nakajima Hiroshi Kunugi 《World Journal of Biological Chemistry》 2014年第4期409-428,共20页
Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to ... Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has beenreported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer's disease, Huntington's disease, depression and schizophrenia. 展开更多
关键词 Brain-derived neurotrophic factor Transcription Transport Secretion Neurodegenerative disorders Psychiatric disorders
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DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats 认领 引用 被引量：5
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作者 Li, Z. Cui, S. Z. +4 位作者 Zhang, Z. Zhou, R. Ge, Y. B. Sokabe, M. Chen, L. 《南京医科大学学报（自然科学版）》 CAS 北大核心 2009年第4期511-511,共1页
Dehydroepiandrosterone（DHEA） has been implicated not only to prevent N-methyl-D-aspartate（NMDA）-induced neurotoxicity but also to enhance Ca2＋ influx through NMDA receptor（NMDAr）. However, these DHEA effects, w... Dehydroepiandrosterone（DHEA） has been implicated not only to prevent N-methyl-D-aspartate（NMDA）-induced neurotoxicity but also to enhance Ca2＋ influx through NMDA receptor（NMDAr）. However, these DHEA effects, which would produce inconsistent outcomes about neuronal damages, are not well studied in ischemia-induced cerebral damages. Herein, we report that a single administration of DHEA（20 mg/kg） during 3 to 48 h after transient global cerebral ischemia in rats exerted neuroprotective effects such as reduction of isehemia-induced neuronal death in the hippoeampal CA1 and improvement of ischemia-induced deficits in spatial learning. 展开更多
关键词 DHEA 肿瘤 临床 研究
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Functional interactions between steroid hormones and neurotrophin BDNF 认领 引用 被引量：9
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作者 Tadahiro Numakawa Daisaku Yokomaku +3 位作者 Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi 《World Journal of Biological Chemistry》 2010年第5期133-143,共11页
Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS)... Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS) .Though BDNF has two types of receptors,high affinity tropomyosin-related kinase(Trk) B and low affinity p75 receptors,BDNF positively exerts its biological effects on neurons via activation of TrkB and of resultant intracellular signaling cascades including mitogenactivated protein kinase/extracellular signal-regulated protein kinase,phospholipase Cγ,and phosphoinositide 3-kinase pathways.Notably,it is possible that alteration in the expression and/or function of BDNF in the CNS is involved in the pathophysiology of various brain diseases such as stroke,Parkinson's disease,Alzheimer's disease,and mental disorders.On the other hand,glucocorticoids,stress-induced steroid hormones,also putatively contribute to the pathophysiology of depression.Interestingly,in addition to the reduction in BDNF levels due to increased glucocorticoid exposure,current reports demonstrate possible interactions between glucocorticoids and BDNF-mediated neuronal functions. Other steroid hormones,such as estrogen,are involved in not only sexual differentiation in the brain,but also numerous neuronal events including cell survival and synaptic plasticity.Furthermore,it is well known that estrogen plays a role in the pathophysiology of Parkinson's disease,Alzheimer's disease,and mental illness,while serving to regulate BDNF expression and/or function.Here,we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones(glucocorticoids and estrogen). 展开更多
关键词 Brain-derived neurotrophic factor Steroid hormones Neurotrophin Glucocorticoid Estrogen Tropomyosin-related kinase Extracellular signal-regulated protein kinase Phospholipase Cγ Phosphoinositide 3-kinase
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Japanese Science and Technology Basic Plan: A Perspective of Policy Process 认领 引用 被引量：1
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作者 Yukihide Hayashi 《Innovation and Development Policy》 2019年第1期24-38,共15页
The Japanese government formulates the Science and Technology Basic Plan every five years based on the Science and Technology Basic Law, and indicates the future direction of Japan’s science and technology. This pape... The Japanese government formulates the Science and Technology Basic Plan every five years based on the Science and Technology Basic Law, and indicates the future direction of Japan’s science and technology. This paper describes its history, significance, and decision process of this Science and Technology Basic Plan. Then this paper describes the characteristics of the previous five plans, contributions to Japanese science and technological activities, and its challenges for the future. In the formulation of the Science and Technology Basic Plan, the role of the Council for Science and Technology Policy has been significant. However, after establishing Shinzo Abe administration, the inclination to global innovation has been emphasized in Japan as well, the Council for Science and Technology Policy was renamed the Council for Science, Technology and Innovation, and the midterm and annual strategies centered on innovation have also been prepared. This paper described these movements.Japan suffers from population decline and the increase in governmental deficits, and there is also a tendency towards weakness in science and technology innovation. To formulate more suitable science and technology basic plans will revitalize and strengthen Japan’s science and technology innovation. 展开更多
关键词 science and technology agency science and technology basic law science and technology basic plan five years plan council for science and technology policy the council for science technology and innovation Shinzo Abe Japan
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