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Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development:A pilot study 认领 引用
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作者 Nobue Futawatari Takashi Fukuyama +7 位作者 Yusuke Akimoto Junji Maehara Daisuke Hihara Yosuke Okamoto Yuki Yokouchi Kei Takahashi Manabu Watanabe Yoshihisa Saida 《World Journal of Clinical Oncology》 2026年第1期202-211,共10页
BACKGROUND We have previously reported that the cancerestis antigen Kita-Kyushu lung cancer antigen-1(KK-LC-1)is frequently expressed in gastric cancer(GC),with a particularly high positivity rate observed in patients... BACKGROUND We have previously reported that the cancerestis antigen Kita-Kyushu lung cancer antigen-1(KK-LC-1)is frequently expressed in gastric cancer(GC),with a particularly high positivity rate observed in patients with multiple GCs.Thus,we conducted a preliminary study to further investigate the relationship between KK-LC-1 expression and multiple GCs.Specifically,we aimed to explore the potential clinical utility of KK-LC-1 as a biomarker for identifying patients at risk of developing multiple gastric cancers,with a focus on its expression in the initial tumor lesions.AIM To investigate the association between KK-LC-1 expression and the development of multiple GCs in a preliminary cohort.METHODS Among 124 patients(177 lesions)treated for GC at Toho University Medical Center Ohashi Hospital between September 2020 and November 2023,109(single cancer:82;multiple cancers:27)with available initial tumor specimens were enrolled.KK-LC-1 expression was assessed using immunohistochemistry,and clinicopathological correlations were analyzed using Fisher’s exact test.Tumor locations were classified anatomically and analyses were performed,focusing on the initial cancer sites.RESULTS In tumors located in the upper stomach,KK-LC-1 expression did not correlate with clinicopathological features.However,in the middle and lower stomach,KK-LC-1 expression was significantly associated with older age,differentiated histological types,and multiple cancers.Notably,all patients with multiple GCs had KK-LC-1-positive tumors(100%)in their initial lesions.The KK-LC-1 positivity rate in the initial tumors of multiple cancers in the middle and lower region was significantly higher than that in solitary cancers.Conversely,the absence of KK-LC-1 expression in a solitary tumor located in the middle and lower region may suggest a reduced risk for the subsequent development of multiple primary cancers.CONCLUSION KK-LC-1 expression in the initial gastric tumors,particularly in the middle and lower stomach regions,may serve as a predictive biomarker for the future development of multiple GCs. 展开更多
关键词 Gastric cancer Kita-Kyushu lung cancer antigen-1 Multiple cancers Prognostic marker Tumor differentiation
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粉防己中双苄基异喹啉类生物碱成分研究 认领 引用
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作者 范春雨 张翔宇 +3 位作者 马建彤 龚卓凡 李巍 丁丽琴 《中国药物化学杂志》 CAS 2026年第2期110-118,共9页
目的对粉防己(Stephania tetrandra S.Moore)中的双苄基异喹啉类生物碱成分进行研究。方法采用多种色谱、波谱技术对粉防己95%(体积分数)乙醇提取物中生物碱成分进行分离纯化与结构鉴定。结果从粉防己95%(体积分数)乙醇提取物中分离得到... 目的对粉防己(Stephania tetrandra S.Moore)中的双苄基异喹啉类生物碱成分进行研究。方法采用多种色谱、波谱技术对粉防己95%(体积分数)乙醇提取物中生物碱成分进行分离纯化与结构鉴定。结果从粉防己95%(体积分数)乙醇提取物中分离得到9个双苄基异喹啉类生物碱,分别为3,4-二氧汉防己乙素(1)、汉防己甲素(2)、汉防己乙素(3)、氧化防己碱(4)、cycleahomine chloride(5)、千金藤素(6)、(1R,1′S)-N-formylisotetrandrine(7)、N-chloromethyltetrandrine(8)、thalrugosidine(9)。结论化合物1为新化合物,化合物6、7为首次从粉防己中分离得到,化合物9为首次从千金藤属植物中分离得到。 展开更多
关键词 粉防己 化学成分 结构鉴定 双苄基异喹啉类生物碱
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Neuronal guidance signaling in neurodegenerative diseases:Key regulators that function at neuron-glia and neuroimmune interfaces 认领 引用 被引量：1
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作者 Junichi Yuasa-Kawada Mariko Kinoshita-Kawada +6 位作者 Masaki Hiramoto Satoru Yamagishi Takayasu Mishima Shin’ichiro Yasunaga Yoshio Tsuboi Nobutaka Hattori Jane Y.Wu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期612-635,共24页
The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their recept... The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their receptors,and downstream signal transducers,organize neural wiring to generate the complex architecture of the nervous system.It is now evident that many of these neuroguidance cues and their receptors are active during development and are also expressed in the adult nervous system.This suggests that neuronal guidance pathways are critical not only for neural wiring but also for ongoing function and maintenance of the mature nervous system.Supporting this view,these pathways continue to regulate synaptic connectivity,plasticity,and remodeling,and overall brain homeostasis throughout adulthood.Genetic and transcriptomic analyses have further revealed many neuronal guidance genes to be associated with a wide range of neurodegenerative and neuropsychiatric disorders.Although the precise mechanisms by which aberrant neuronal guidance signaling drives the pathogenesis of these diseases remain to be clarified,emerging evidence points to several common themes,including dysfunction in neurons,microglia,astrocytes,and endothelial cells,along with dysregulation of neuron-microglia-astrocyte,neuroimmune,and neurovascular interactions.In this review,we explore recent advances in understanding the molecular and cellular mechanisms by which aberrant neuronal guidance signaling contributes to disease pathogenesis through altered cell-cell interactions.For instance,recent studies have unveiled two distinct semaphorin-plexin signaling pathways that affect microglial activation and neuroinflammation.We discuss the challenges ahead,along with the therapeutic potentials of targeting neuronal guidance pathways for treating neurodegenerative diseases.Particular focus is placed on how neuronal guidance mechanisms control neuron-glia and neuroimmune interactions and modulate microglial function under physiological and pathological conditions.Specifically,we examine the crosstalk between neuronal guidance signaling and TREM2,a master regulator of microglial function,in the context of pathogenic protein aggregates.It is well-established that age is a major risk factor for neurodegeneration.Future research should address how aging and neuronal guidance signaling interact to influence an individual’s susceptibility to various late-onset neurological diseases and how the progression of these diseases could be therapeutically blocked by targeting neuronal guidance pathways. 展开更多
关键词 amyloid-β axon guidance neurodegeneration neuroimmune interactions neuroinflammation neuron-glia interactions neurovascular interactions semaphorin synaptic remodeling tau TDP-43 TREM2 α-synuclein
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Anastomotic colonic varices after colectomy treated by obliteration via a transhepatic portal approach:A case report 认领 引用
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作者 Daisuke Tomita Masayoshi Yamamoto +8 位作者 Masato Wakamatsu Ryo Shibayama Yusuke Maeda Kosuke Hiramatsu Yutaka Hanaoka Shigeo Toda Masashi Ueno Shuichiro Matoba Hiroya Kuroyanagi 《World Journal of Gastroenterology》 SCIE CAS 2026年第18期109-117,共9页
BACKGROUND Colonic anastomotic varices are extremely rare,particularly in patients without portal hypertension.Their clinical presentation is often nonspecific,and standardized diagnostic and therapeutic strategies ha... BACKGROUND Colonic anastomotic varices are extremely rare,particularly in patients without portal hypertension.Their clinical presentation is often nonspecific,and standardized diagnostic and therapeutic strategies have not yet been established.We report a unique case of recurrent lower gastrointestinal bleeding from transverse colonic anastomotic varices in a noncirrhotic patient who was successfully treated with percutaneous embolization.CASE SUMMARY A 65-year-old man with a history of laparoscopic transverse colectomy presented with recurrent melena at 30-,35-,and 38-month postoperatively.Colonoscopy repeatedly demonstrated active bleeding from dilated submucosal veins at the anastomotic site,and endoscopic clipping provided only temporary hemostasis.Laboratory tests revealed preserved hepatic function,and imaging revealed no findings suggestive of portal hypertension.Due to refractory bleeding and the invasive nature of the reoperation,an interventional radiology(IR)approach was selected.Computed tomography portography revealed venous convergence in both the superior and inferior mesenteric systems at the anastomotic site.Targeted embolization via the transhepatic portal approach successfully achieved complete obliteration of varices.The patient did not experience further bleeding during the months of follow-up.CONCLUSION IR is an effective and minimally invasive treatment option for refractory anastomotic colonic varices in patients without portal hypertension. 展开更多
关键词 Anastomotic varices Colonic varices Lower gastrointestinal bleeding Normal portal pressure Interventional radiology Transhepatic portal approach Computed tomography portography Variceal obliteration Case report
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Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348 认领 引用 被引量：2
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作者 Kazuhiro Ooka Atsushi Fukumoto +4 位作者 Tomoe Yamanaka Kanako Shimada Ryo Ishihara Yojiro Anzai Fumio Kato 《Open Journal of Medicinal Chemistry》 2013年第4期93-99,共7页
Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is we... Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is well known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence, biofilm formation, swarming motility, antibiotic biosynthesis, and virulence factor production. C. violaceum CV026 is commonly used to determine qualitative and quantitative QS activity. The structures of piericidin derivatives were characterized, and their QS activities were determined. 展开更多
关键词 Piericidin A1 3’-Rhamnopiericidin A1 Piericidin E Quorum-Sensing Inhibitor Chromobacterium violaceum CV026 N-Acylhomoserinlactone
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Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica 认领 引用 被引量：4
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作者 Juan Zhang Jiankun Yan +7 位作者 Hongjun Dong RuiZhang Jing Chang Yanli Feng Xinrong Xu Wei Li Feng Qiu Chengpeng Sun 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第8期961-971,共11页
In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed ... In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed to investigate chemical constituents from Inula Britannica(I.britannica).Seven novel sesquiterpenoid dimers inulabritanoids A−G(1−7)and two novel sesquiterpenoid monomers inulabritanoids H(8)and I(9)were isolated from I.britannica together with eighteen known compounds(10−27).The structural elucidation was accomplished through comprehensive analysis of 1D and 2D nuclear magnetic resonance(NMR),high-resolution mass spectrometry(HR-MS),and electronic circular dichroism(ECD)spectra,complemented by quantum chemical calculations.Compounds 1,2,12,16,19,and 26 demonstrated inhibitory effects on NO production,with IC50 values of 3.65,5.48,3.29,6.91,3.12,and 5.67μmol·L−1,respectively.Mechanistic studies revealed that compound 1 inhibited IκB kinaseβ(IKKβ)phosphorylation,thereby blocking nuclear factorκB(NF-κB)nuclear translocation,and activated the kelch-like ECH-associated protein 1(Keap1)uclear factor erythroid 2-related factor 2(Nrf2)signal pathway,leading to decreased expression of NADPH oxidase 2(NOX-2),inducible nitric oxide synthase(iNOS),tumor necrosis factorα(TNF-α),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),IL-1β,and IL-1αand increased expression of NAD(P)H:quinone oxidoreductase 1(NQO-1)and heme oxygenase-1(HO-1),thus exhibiting anti-inflammatory effects in vitro.These results indicate that dimeric sesquiterpenoids may serve as promising candidates for anti-inflammatory drug development. 展开更多
关键词 Inula britannica Sesquiterpenoid dimers Anti-inflammatory effects Mechanism Keap1-Nrf2
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Field-based Simplified Approach of Evaluating Knee Extensor Muscle Strength and Size in Male University Freshmen 认领 引用
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作者 Tomohiro Yasuda Daisuke Ichikawa 《Journal of Sports Science》 2016年第5期272-278,共7页
The purpose of this study was to examine the relationship between field-based simplified approaches and knee extensor muscle strength/size in young men. Knee extensor muscle thickness （MT） of 104 healthy university ... The purpose of this study was to examine the relationship between field-based simplified approaches and knee extensor muscle strength/size in young men. Knee extensor muscle thickness （MT） of 104 healthy university freshmen was measured at the anterior half of thigh length; maximal voluntary isometric contraction （MVIC） was measured when subjects performed knee extension. Field-based simplified approaches [sit-to-stand, standing long jump （SLJ）, handgrip and upper-leg-50% （thigh） girth] were also measured. MVIC was correlated with SLJ （r = 0.361, P 〈 0.001）, handgrip （r = 0.523, P 〈 0.001） and thigh girth （r = 0.401, P 〈 0.001）, but not with the sit-to-stand test （r = 0.126, P 〉 0.05）. MT was correlated with handgrip （r = 0.317, P 〈 0.001） and thigh girth （r = 0.632, P 〈 0.001）, but not with SLJ （r = 0.038, P 〉 0.05） or the sit-to-stand test （r = 0.145, P 〉 0.05）. A stepwise multiple-regression analysis was applied to the predictor thigh girth to predict knee extensor MT （R2 = 0.399）. To predict knee extensor MVIC, the predictor handgrip, thigh girth and SLJ were applied （R2 = 0.381）. In conclusion, knee extensor muscle strength/size could be evaluated by the field-based simplified approaches, in particular by the thigh girth measurement, which may be major determinant to maintain activities of daily living for healthy young men. However, the 4 field-based simplified approaches appear to be still not of high impact. 展开更多
关键词 Physical fitness test standing broad jump chair stand knee extension muscle thickness.
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Immune Checkpoint Inhibitors in Gastrointestinal Cancers: Current Evidence and Future Directions 认领 引用
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作者 Takeshi Toyozumi Hideaki Shimada Hisahiro Matsubara 《Oncology Research》 SCIE 2025年第11期3185-3206,共22页
Cancer immunotherapy has long been established as an important treatment option for cancers.In particular,Immune Checkpoint Inhibitor(ICI)has been reported to be effective against various gastrointestinal cancers(esop... Cancer immunotherapy has long been established as an important treatment option for cancers.In particular,Immune Checkpoint Inhibitor(ICI)has been reported to be effective against various gastrointestinal cancers(esophageal cancer,gastric cancer,colorectal cancer);however,the treatment phase in which ICI should be used and how it should be incorporated into the treatment strategy vary depending on the cancer type being treated.Multiple clinical trials and basic research on ICIs are currently underway,and new insights from these results will continue to change the clinical treatment strategy of gastrointestinal cancers.While it is desirable to have an increasing number of treatment strategy options for gastrointestinal cancers,it is necessary to organize increasingly complex treatments and select more appropriate ICI-based treatments.In addition,as gastrointestinal cancers are being controlled through multidisciplinary treatment using ICI-based treatment,local control by conversion surgery is becoming an important treatment option.We may soon see an era in which gastrointestinal cancers can be systematically controlled with ICIbased treatment,while difficult-to-control lesions can be removed by conversion surgery.In this review,we summarize the evidence of ICI-based treatment for gastrointestinal cancers and provide an overview of the treatment strategies currently underway. 展开更多
关键词 Immune checkpoint inhibitors gastrointestinal tumor conversion surgery
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Effect of family history on detection of adenomas and sessile serrated lesions in individuals aged 40s 认领 引用
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作者 Osamu Toyoshima Toshihiro Nishizawa +7 位作者 Hiroki Asano Mari Mizutani Takeshi Uozumi Ai Fujimoto Masaya Sano Shuntaro Yoshida Keisuke Hata Hirotoshi Ebinuma 《World Journal of Gastrointestinal Endoscopy》 2025年第10期109-115,共7页
BACKGROUND According to the guidelines in the United States,individuals with a family history of colorectal cancer should be screened at the age of 40 years.Data on the prevalence of adenomas and sessile serrated lesi... BACKGROUND According to the guidelines in the United States,individuals with a family history of colorectal cancer should be screened at the age of 40 years.Data on the prevalence of adenomas and sessile serrated lesions(SSLs)in individuals aged 40-49 years in Japan are lacking.AIM To investigate the effect of family history on the detection of adenomas and SSLs during colonoscopy in Japan.METHODS This retrospective,single-center cohort study included individuals aged 40-79 years who underwent colonoscopy by expert endoscopists with an adenoma detection rate(ADR)≥40%between 2021 and 2024.The ADR and adenoma plus SSL detection rate(ASDR)were investigated according to age.Multivariable analyses were performed to examine the effects of first-degree family history of colorectal cancer,fecal immunochemical test,and sex on the ADR and ASDR for each age group.A binomial logistic regression model was used.RESULTS In 10248 participants,the overall ADR and ASDR were 53.6%and 59.1%,respectively.The ADR and ASDR increased with age.Among 2317 participants aged 40-49 years,the presence of a family history significantly increased the ADR(47.6%vs 38.2%).The odds ratio of a family history for the ADR adjusted by sex and fecal immunochemical test was 1.59(95%confidence interval:1.13-2.25).In contrast,there was no significant association between the ADR and family history in participants aged 50-59,60-69,and 70-79 years.Similarly,a family history significantly increased the ASDR(58.0%vs 43.7%)in participants aged 40-49 years.The odds ratio of a family history for the ASDR was 1.92(95%confidence interval:1.36-2.71).CONCLUSION Participants with a family history exhibited significantly elevated ADR(47.6%)and ASDR(58.0%),in their 40s.Individuals with a family history should initiate colonoscopy at 40 years old. 展开更多
关键词 Age Family history Colorectal neoplasia Colonoscopy Sessile serrated lesions
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Surgical Experience with Scoliosis Associated with Adolescent Turner Syndrome: Two Case Reports and a Literature Review 认领 引用
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作者 Akihito Wada Takashi Dezawa +4 位作者 Kazumasa Nakamura Keiji Hasegawa Katsunori Fukutake Akinori Tani Hiroshi Takahashi 《Open Journal of Orthopedics》 2025年第2期69-77,共9页
Background: Turner syndrome (TS) affects approximately one in 2500 live births in females. Scoliosis is one of the skeletal manifestations of TS, but most cases only require observation or conservative treatment. We e... Background: Turner syndrome (TS) affects approximately one in 2500 live births in females. Scoliosis is one of the skeletal manifestations of TS, but most cases only require observation or conservative treatment. We experienced two adolescent TS cases in which progression of scoliosis required surgical intervention, which is very rare in TS. Case Presentation: Case 1: An 11-year-old female with TS had a single thoracic curve that rapidly progressed to a triple major curve with a 76˚ main thoracic curve at age 13.5 years. Case 2: A 14-year-old female with TS had a 59˚ single thoracic curve. In both cases, growth hormone and estrogen replacement therapy were administered preoperatively and planned postoperatively. Posterior correction and instrumented fusion using simultaneous translation on two rods technique and direct vertebral rotation with the use of multiple rod introducers were successfully performed in both cases. No crankshaft phenomenon or distal adding on were observed during those postoperative courses. Conclusions: Although curve pattern of the deformity is similar to adolescent idiopathic scoliosis (AIS), bone quality in patient with TS is lower. In the context of surgical interventions for scoliosis associated with TS, it is imperative to employ surgical techniques that take into account the suboptimal bone quality. If continuation of hormone replacement therapy is planned after corrective surgery for scoliosis in TS patients, it is essential to follow the patient closely postoperatively until bone maturation is complete. 展开更多
关键词 Turner Syndrome Scoliosis Hormone Replacement Therapy Simultaneous Translation on Two Rods Rod Introducer
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Pigmented Villonodular Synovitis of the Spine: Two Case Reports and a Literature Review 认领 引用
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作者 Kazumasa Nakamura Hiroshi Takahashi +2 位作者 Katsunori Fukutake Keiji Hasegawa Akihito Wada 《Open Journal of Orthopedics》 2025年第1期31-40,共10页
Introduction: Pigmented villonodular synovitis (PVNS) of the spine is a rare condition, with only a limited number of cases documented in the medical literature. In this study, we review imaging findings of two cases ... Introduction: Pigmented villonodular synovitis (PVNS) of the spine is a rare condition, with only a limited number of cases documented in the medical literature. In this study, we review imaging findings of two cases of PVNS arising in the spine. Case 1: A 52-year-old male presented with right thigh pain of unclear etiology. His condition subsequently deteriorated and he was referred to our hospital. MRI revealed a spinal tumor with high intensity on T1-weighted imaging (T1WI) and iso-intensity on T2WI in the right L2/3 intervertebral foramen. The tumor exhibited heterogeneous enhancement on contrast-enhanced MRI. Computed tomography (CT) myelography showed the presence of an epidural tumor within the right L2/3 intervertebral foramen, situated externally to the spinal canal and compressing the dura mater. Notable scalloping was observed in the posterior margin of the L2 vertebral body on CT images. Case 2: A 78-year-old male presented with a complaint of muscle weakness of the left upper limb. His gait gradually deteriorated, which led to suspicion of cervical myelopathy. A tumor was observed on plain MRI and exhibited low to iso-intensity on T1WI and high intensity on T2WI. The tumor was in the left C7/T1 intervertebral segment and the spinal cord was compressed from the left side. CT showed destruction of the medial aspect of the left C7 vertebral arch. Conclusion: In spinal PVNS, the signal intensity on MRI is dependent on the timing of hemorrhage within the tumor, and there are no distinctive features. However, if an extradural tumor is suspected and CT shows bone erosion, scalloping or osteolytic changes, PVNS should be considered as a differential diagnosis. 展开更多
关键词 Spinal Pigmented Villonodular Synovitis Imaging Diagnosis Computed Tomography Magnetic Resonance Imaging
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Highly anticipated natural diterpenoids as an important source of new drugs in 2013-2023 认领 引用
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作者 Yingjie Wang Peng Tang +15 位作者 Wenchao Tu Qi Gao Cuizhu Wang Luying Tan Lixin Zhao Hongye Han Liefeng Ma Kouharu Otsuki Weilie Xiao Wenli Wang Jinping Liu Yong Li Zhajun Zhan Wei Li Xianli Zhou Ning Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第1期119-136,共18页
This review covers the structures of diterpenoids,including chain(72),monocyclic(9),labdane-type(67),clerodane-type(127)abietane-type(716),ent-kaurane-type(89),grayanane-type(331),ingenanetype(55),tigliane-type(154),d... This review covers the structures of diterpenoids,including chain(72),monocyclic(9),labdane-type(67),clerodane-type(127)abietane-type(716),ent-kaurane-type(89),grayanane-type(331),ingenanetype(55),tigliane-type(154),daphnane-type(237),and aconitine-type diterpene alkaloids(265)with rich biological activities reported in 2013-2023.And the drugs in clinical use or under clinical investigation of diterpenoids and leading compounds were summarized. 展开更多
关键词 Natural diterpenoids Structures Bioactivities Druggability Leading compounds New drugs
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热休克蛋白在呼吸系统疾病中的作用及中药干预的研究进展 认领 引用
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作者 邓心悦 姚铁 +2 位作者 邱峰 曹世杰 李巍 《中南药学》 CAS 2025年第11期3298-3304,共7页
热休克蛋白(HSPs)作为一类重要的分子伴侣蛋白,在机体内参与多种生物过程。HSPs与多种呼吸系统疾病密切相关,可能是潜在的临床治疗靶点。中药及其活性成分通过影响HSPs及其下游蛋白的表达、调控HSPs相关复合物的形成、减轻气道炎症、降... 热休克蛋白(HSPs)作为一类重要的分子伴侣蛋白,在机体内参与多种生物过程。HSPs与多种呼吸系统疾病密切相关,可能是潜在的临床治疗靶点。中药及其活性成分通过影响HSPs及其下游蛋白的表达、调控HSPs相关复合物的形成、减轻气道炎症、降低氧化应激、抑制肺癌细胞的侵袭和迁移、促进肿瘤细胞凋亡等发挥治疗肺部相关疾病的作用。本文综述了HSPs在呼吸系统疾病中的作用以及中药干预HSPs治疗急性肺损伤、慢性阻塞性肺疾病、哮喘、肺癌等的进展,以期为中药机制研究和临床应用提供理论参考和科学依据。 展开更多
关键词 热休克蛋白 呼吸系统疾病 中药活性成分 中药复方
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甘草黄酮的抗抑郁作用及对海马脑区神经再生的保护作用 认领 引用 被引量：58
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作者 樊紫周 赵伟鸿 +6 位作者 果嘉 程瑞凤 赵金英 杨卫东 王英华 李巍 彭晓东 《药学学报》 CAS CSCD 北大核心 2012年第12期1612-1617,共6页
观察宁夏地区栽培甘草(Glycyrrhiza uralensis Fisch.)中获得的甘草总黄酮提取部位(licorice flavonoids,LF)对大鼠慢性不可预见性应激抑郁模型(chronic unpredicted stress model of depression,CUS)的干预作用及对模型造成的海马齿状... 观察宁夏地区栽培甘草(Glycyrrhiza uralensis Fisch.)中获得的甘草总黄酮提取部位(licorice flavonoids,LF)对大鼠慢性不可预见性应激抑郁模型(chronic unpredicted stress model of depression,CUS)的干预作用及对模型造成的海马齿状回(dentate gyrus,DG)颗粒细胞层下区(subgranular zone,SGZ)神经再生(neurogenesis)能力损害的保护作用,研究LF抗抑郁作用及可能的机制。通过对大鼠实施9种不同的刺激建立慢性应激抑郁模型,造模28天的同时采用不同剂量的LF(300、100和30 mg.kg-1)连续干预。采用旷场实验(open field test,OFT)、强迫游泳实验(forced swimming test,FST)和悬尾实验(tail suspension test,TST)判断LF的抗抑郁作用,放免法测定血清皮质酮含量,共聚焦显微镜对海马齿状回SGZ中5-溴脱氧尿嘧啶核苷(5'-bromo-2'-deoxyuridine,BrdU)标记的新生祖细胞(progenitor)进行分析、计数。与模型组相比,LF能够增加旷场实验中抑郁模型大鼠的直立次数、穿格数及减少粪便粒数;减少强迫游泳实验和悬尾实验中抑郁模型大鼠的不动时间;300 mg.kg-1剂量LF能降低血清皮质酮水平,同时恢复大鼠海马齿状回SGZ中BrdU标记的新生祖细胞数量。结果提示,甘草总黄酮提取部位对慢性不可预测应激引起的大鼠抑郁行为具有良好的抗抑郁药理活性,并且在较大剂量下能对应激引起的海马神经再生损害起到保护作用。 展开更多
关键词 甘草 黄酮 抑郁症 应激 神经再生 5-溴脱氧尿嘧啶核苷
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Strategy to differentiate autoimmune pancreatitis from pancreas cancer 认领 引用 被引量：27
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作者 Kensuke Takuma Terumi Kamisawa +5 位作者 Rajesh Gopalakrishna Seiichi Hara Taku Tabata Yoshihiko Inaba Naoto Egawa Yoshinori Igarashi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第10期1015-1020,共6页
Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organ... Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic "IgG4-related sclerosing disease". Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers. It is of uppermost importance not to misdiagnose AIP as pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, and approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological, and histopathological features. Findings suggesting AIP rather than pancreatic cancer include:fluctuating obstructive jaundice; elevated serum IgG4 levels; diffuse enlargement of the pancreas; delayed en- hancement of the enlarged pancreas and presence of a capsule-like rim on dynamic computed tomography; low apparent diffusion coefficient values on diffusion-weighted magnetic resonance image; irregular narrowing of the main pancreatic duct on endoscopic retrograde cholangiopancreatography; less upstream dilatation of the main pancreatic duct on magnetic resonance cholangiopancreatography, presence of other organ involvement such as bilateral salivary gland swelling, retroperitoneal fibrosis and hilar or intrahepatic sclerosing cholangitis; negative work-up for malignancy including endoscopic ultrasound-guided fine needle aspiration; and steroid responsiveness. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection. 展开更多
关键词 Autoimmune pancreatitis Pancreatic cancer Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography
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Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan 认领 引用 被引量：25
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作者 Toshio Kurihara Ichiro Yasuda +18 位作者 Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi 《World Journal of Gastroenterology》 SCIE CAS 2016年第5期1891-1901,共11页
AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prosp... AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. 展开更多
关键词 Cholangioscopy Endoscopic retrogradecholangiopancreatography Pancreatoscopy Singleoperator SpyGlass
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海南山苦茶叶的化学成分研究Ⅰ 认领 引用 被引量：30
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作者 林连波 符小文 +3 位作者 艾朝晖 申静 卫昆 李魏 《中国中药杂志》 CAS 北大核心 2006年第6期477-479,共3页
目的:研究海南山苦茶叶的化学成分。方法:运用溶剂法和色谱法进行成分的分离和纯化,通过理化性质和光谱数据的解析,鉴定化合物的结构。结果:首次从海南山苦茶叶中分离出8个化合物,分别鉴定为3-羟基-4,5(R)-二甲基-2(5H)-呋喃酮(Ⅰ),没... 目的:研究海南山苦茶叶的化学成分。方法:运用溶剂法和色谱法进行成分的分离和纯化,通过理化性质和光谱数据的解析,鉴定化合物的结构。结果:首次从海南山苦茶叶中分离出8个化合物,分别鉴定为3-羟基-4,5(R)-二甲基-2(5H)-呋喃酮(Ⅰ),没食子酸(Ⅱ),(6S,9R)-6-羟基-3-酮-α-紫罗兰醇-9-O-β-D-葡萄糖苷(Ⅲ),(Z)-3-己烯醇-β-D-葡萄糖苷(Ⅳ),3,4,8,9,10-五羟基-二苯并[b,d]吡喃-6-酮(Ⅴ),木栓醇(Ⅵ),β-谷甾醇(Ⅶ),木栓酮(Ⅷ)。结论:以上化合物均为首次从该植物中获得。 展开更多
关键词 海南山苦茶 化学成分 木栓醇 木栓酮
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甘草总黄酮抗抑郁作用研究 认领 引用 被引量：21
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作者 果嘉 赵伟鸿 +6 位作者 樊紫周 程瑞凤 赵金英 杨卫东 王英华 李巍 彭晓东 《中药药理与临床》 CAS CSCD 北大核心 2012年第6期59-62,共4页
目的:研究甘草总黄酮(FEPs)的抗抑郁作用。方法:雄性SD大鼠正常组、模型组、甘草黄酮组(30、100、300mg/kg)、阳性药物氟西汀组各10只,采用成年大鼠慢性不可预测温和应激模型(CUMS),连续给药28天后,采用旷场实验(OFT)、强迫游泳实验(FST... 目的:研究甘草总黄酮(FEPs)的抗抑郁作用。方法:雄性SD大鼠正常组、模型组、甘草黄酮组(30、100、300mg/kg)、阳性药物氟西汀组各10只,采用成年大鼠慢性不可预测温和应激模型(CUMS),连续给药28天后,采用旷场实验(OFT)、强迫游泳实验(FST)、悬尾实验(TST),并实施血清皮质酮检测,判断甘草总黄酮的抗抑郁作用。雄性昆明小鼠正常组、甘草黄酮组(5、30、180mg/kg)、阳性药物组氟西汀各16只,连续21天给药,并在实验第1、7、21天进行自主活动实验监测,观察FEPs的中枢作用特点。结果:与模型组相比较,甘草总黄酮(30、100、300mg/kg)干预后,大鼠在旷场实验中表现直立次数增多、穿格数增多、粪便粒数明显减少;强迫游泳不动时间明显减少;悬尾实验不动时间明显减少;甘草黄酮300mg/kg剂量干预后血清皮质酮明显低于模型组;甘草总黄酮对供试小鼠无中枢兴奋作用。结论:甘草总黄酮具有抗大鼠慢性不可预测温和应激模型引起的行为抑郁作用,且无中枢兴奋的不良反应。 展开更多
关键词 甘草 黄酮 抑郁症 应激 行为 皮质酮
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栽培甘草中甘草黄酮提取物对糖尿病大鼠血糖血脂的调节作用 认领 引用 被引量：23
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作者 赵金英 杨卫东 +3 位作者 李红兵 王英华 李巍 彭晓东 《时珍国医国药》 CAS CSCD 北大核心 2012年第1期101-103,共3页
目的观察宁夏地区栽培甘草提取物甘草黄酮(licorice flavonoids,LF)对2型糖尿病(Type II Diabetes Mellitus,T2DM)模型大鼠的降糖、降脂作用及相关机制研究。方法采用高脂高糖饮食喂养后(12周)行低剂量链脲佐菌素(strep-tozotocin,STZ,3... 目的观察宁夏地区栽培甘草提取物甘草黄酮(licorice flavonoids,LF)对2型糖尿病(Type II Diabetes Mellitus,T2DM)模型大鼠的降糖、降脂作用及相关机制研究。方法采用高脂高糖饮食喂养后(12周)行低剂量链脲佐菌素(strep-tozotocin,STZ,35 mg/kg,ip)造模的大鼠2型糖尿病模型,将实验大鼠分为正常对照组、模型对照组、二甲双胍(metformin,Met)组、甘草黄酮组(100,300 mg/kg),实施40d干预后,测定空腹血糖、血浆糖化血红蛋白(HbA1C)、尿糖值,24 h尿蛋白值和酮体值;测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和游离脂肪酸(FFA)含量;测定血清超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)和总抗氧能力(T-AOC)。结果 LF降低空腹血糖、降低HbA1C水平、降低尿糖值;升高血浆HDL-C含量,而对于血浆TC、TG、LDL和FFA的含量作用不明显。LF可以升高血清SOD和GSH-PX水平的同时降低血清MDA含量,并能够调节NOS水平,进而改善血浆中NO的含量。而LF对血浆T-AOC、24 h尿蛋白值和酮体值,改善不明显。结论宁夏地区栽培甘草提取物中LF具有改善实验性2型糖尿病的作用,并且其调节血脂、抗氧化活性可能与其改善实验性II型糖尿病的机制有关。 展开更多
关键词 甘草 黄酮 糖尿病 链脲佐菌素 抗氧化作用
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Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation 认领 引用 被引量：17
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作者 Kensuke Takuma Terumi Kamisawa +8 位作者 Taku Tabata Seiichi Hara Sawako Kuruma Yoshihiko Inaba Masanao Kurata Goro Honda Koji Tsuruta Shin-ichiro Horiguchi Yoshinori Igarashi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第26期3409-3414,共6页
AIM:To clarify the strategy for early diagnosis of pancreaticobiliary maljunction(PBM) without biliary dilatation and to pathologically examine gallbladder before cancer develops.METHODS:The anatomy of the union of th... AIM:To clarify the strategy for early diagnosis of pancreaticobiliary maljunction(PBM) without biliary dilatation and to pathologically examine gallbladder before cancer develops.METHODS:The anatomy of the union of the pancreatic and bile ducts was assessed by using endoscopic retrograde cholangiopancreatography(ERCP).Patients with a long common channel in which communication between the pancreatic and bile ducts was maintained even during sphincter contraction were diagnosed as having PBM.Of these,patients in which the maximal diameter of the bile duct was less than 10 mm were diagnosed with PBM without biliary dilatation.The process of diagnosing 54 patients with PBM without biliary dilatation was retrospectively investigated.Histopathological analysis of resected gallbladder specimens from 8 patients with PBM without biliary dilatation or cancer was conducted.RESULTS:Thirty-six PBM patients without biliary dilatation were diagnosed with gallbladder cancer after showing clinical symptoms such as abdominal or back pain(n = 16) or jaundice(n = 12).Radical surgery for gallbladder cancer was only possible in 11 patients(31%) and only 4 patients(11%) survived for 5 years.Eight patients were suspected as having PBM without biliary dilatation from the finding of gallbladder wall thickening on ultrasound and the diagnosis was confirmed by ERCP and/or magnetic resonance cholangiopancreatography(MRCP).The median age of these 8 patients was younger by a decade than PBM patients with gallbladder cancer.All 8 patients underwent prophylactic cholecystectomy and bile duct cancer has not occurred.Wall thickness and mucosal height of the 8 resected gallbladders were significantly greater than controls,and hyperplastic changes,hypertrophic muscular layer,subserosal fibrosis,and adenomyomatosis were detected in 7(88%),5(63%),7(88%) and 5(63%) patients,respectively.Ki-67 labeling index was high and K-ras mutation was detected in 3 of 6 patients.CONCLUSION:To detect PBM without biliary dilatation before onset of gallbladder cancer,we should perform MRCP for individuals showing increased gallbladder wall thickness on ultrasound. 展开更多
关键词 Pancreaticobiliary maljunction Pancreato-biliary reflux Ultrasound Gallbladder cancer Endo-scopic ultrasonography
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