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铁死亡及铜死亡在纤维化疾病中的研究进展 认领
Ferroptosis and cuproptosis in fibrotic diseases:research progress
摘要
以铁死亡、铜死亡为中心的金属离子依赖的调控性细胞死亡通路在纤维化疾病中发挥关键作用。铁、铜离子的细胞摄取-储存-外排紊乱引起氧化还原失衡,继而激活经典及非经典TGF-β/Smad通路、驱动上皮-间质转化(EMT)与成纤维...展开更多
Metal ion-dependent regulated cell death pathways,centered on ferroptosis and cuproptosis,play key roles in fibrotic diseases.Disruptions in the cellular uptake,storage,and efflux of iron and copper ions lead to redox imbalance,which subsequently activates the canonical...MORE
Metal ion-dependent regulated cell death pathways,centered on ferroptosis and cuproptosis,play key roles in fibrotic diseases.Disruptions in the cellular uptake,storage,and efflux of iron and copper ions lead to redox imbalance,which subsequently activates the canonical and non-canonical transforming growth factor-β/Smad pathways,drives epithelialmesenchymal transition(EMT)and fibroblast-myofibroblast transition(FMT),and promotes the release of damageassociated molecular patterns to amplify the inflammation-fibrosis loop,thereby promoting organ fibrosis.The mitochondrial tricarboxylic acid cycle serves as a common convergence point of ferroptosis and cuproptosis.Targeted intervention strategies derived from related pathways,including metal ion chelators,traditional Chinese medicine derivatives,small-molecule targeted drugs,and nanomaterials,show favorable anti-fibrotic potential by restoring metal ion homeostasis,blocking EMT/FMT and inhibiting oxidative stress.FEWER
出处
《海军军医大学学报》
CAS
CSCD
北大核心
2026年第8期1083-1089,共7页
Academic Journal of Naval Medical University
基金
国家自然科学基金(82570769,82104257).
分类号
R363
[医药卫生—病理学]
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